Diarrhoeal disease and subsequent risk of death in infants and children residing in low-income and middle-income countries: analysis of the GEMS case-control study and 12-month GEMS-1A follow-on study
A follow-on analysis of the Global Enteric Multicenter Study (GEMS), published in The Lancet Global Health, finds that the risk of death is increased following moderate-to-severe diarrhea and, to a lesser extent, less-severe diarrhea. Considering the higher volume of LSD cases than MSD, more deaths are expected among children with LSD than in those with MSD. Because the major attributable LSD-associated and MSD-associated pathogens are the same, these findings support the implementation of vaccines and rapid diagnosis and treatment interventions against these major pathogens.
Featured Content
Aug 06, 2024
Floods and Diarrhea Risk in Young Children in Low- and Middle-Income Countries
Climate change is associated with more frequent and intense floods. Current research on the association between flood exposure and diarrhea risk is limited mainly to short-term and event-specific analyses. Moreover, how prior drought or water, sanita...
Published Research
Oct 12, 2021
Association of enteropathogen detection with diarrhoea by age and high versus low child mortality settings: a systematic review and meta-analysis
Diarrheal disease can be caused by many different pathogens - including rotavirus, adenovirus, Shigella, enterotoxigenic E. coli, Cryptosporidium, and others - and many models for estimating the burden of diarrheal diseases across populations rely ...
Published Research
May 06, 2020
Mapping geographical inequalities in childhood diarrhoeal morbidity and mortality in low-income and middle-income countries, 2000–17: analysis for the Global Burden of Disease Study 2017
IHME's estimates, published in The Lancet, show that while diarrhea mortality has declined from 2000-2017, uneven subnational burden remains an important factor for policymakers to consider as they target interventions.
Read the full article
Published Research