Aug 06, 2024
Floods and Diarrhea Risk in Young Children in Low- and Middle-Income Countries
Climate change is associated with more frequent and intense floods. Current research on the association between flood exposure and diarrhea risk is limited mainly to short-term and event-specific analyses. Moreover, how prior drought or water, sanita...
Published Research
Oct 12, 2021
Association of enteropathogen detection with diarrhoea by age and high versus low child mortality settings: a systematic review and meta-analysis
Diarrheal disease can be caused by many different pathogens - including rotavirus, adenovirus, Shigella, enterotoxigenic E. coli, Cryptosporidium, and others - and many models for estimating the burden of diarrheal diseases across populations rely ...
Published Research
May 06, 2020
Mapping geographical inequalities in childhood diarrhoeal morbidity and mortality in low-income and middle-income countries, 2000–17: analysis for the Global Burden of Disease Study 2017
IHME's estimates, published in The Lancet, show that while diarrhea mortality has declined from 2000-2017, uneven subnational burden remains an important factor for policymakers to consider as they target interventions.
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Published Research
May 05, 2020
Cost of illness for childhood diarrhea in low- and middle-income countries: a systematic review of evidence and modelled estimates
Diarrhea treatment can be expensive for both families and governments. While many studies have reported on the cost of illness for diarrhea (encompassing both direct medical costs and indirect costs, such as travel and lost income), empirical data...
Published Research
Feb 05, 2020
Introduction of rotavirus vaccination in Palestine: An evaluation of the costs, impact, and cost-effectiveness of ROTARIX and ROTAVAC
Rotavirus vaccines are cost-effective. But a new study by PATH and partners helps policymakers decide among the options using important variables beyond price.
Published Research
Dec 23, 2019
Diarrhoeal disease and subsequent risk of death in infants and children residing in low-income and middle-income countries: analysis of the GEMS case-control study and 12-month GEMS-1A follow-on study
A follow-on analysis of the Global Enteric Multicenter Study (GEMS), published in The Lancet Global Health, finds that the risk of death is increased following moderate-to-severe diarrhea and, to a lesser extent, less-severe diarrhea.
Published Research
Nov 13, 2019
The 2019 report of The Lancet Countdown on health and climate change: ensuring that the health of a child born today is not defined by a changing climate
Children in poor regions will be most affected by climate change-induced diarrheal diseases, via mechanisms such as flooding and the subsequent waterborne illnesses it causes; drought, which reduces availability of nutritious food and can affect h...
Published Research
Oct 30, 2019
Quantifying risks and interventions that have affected the burden of diarrhoea among children younger than 5 years: an analysis of the Global Burden of Disease Study 2017
This paper in The Lancet takes a deep dive to quantify trends and effects of risk factors, interventions, and broader socio-demographic development on diarrhea mortality changes in 195 countries and territories from 1990 to 2017.
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Published Research
Sep 27, 2019
Heterogeneity in Potential Impact and Cost-effectiveness of ETEC and Shigella Vaccination in Four Sub-Saharan African Countries
This analysis shows that the impact and cost-effectiveness of ETEC and Shigella vaccines are more favorable if vaccinations reach the most vulnerable children in underserved provinces. Read the full article.
Published Research
Jun 25, 2019
The incidence, aetiology, and adverse clinical consequences of less severe diarrhoeal episodes among infants and children residing in low-income and middle-income countries: a 12-month case-control study as a follow-on to GEMS
A new study in The Lancet Global Health, published alongside this commentary, summarizes a 12-month case-control study conducted as a follow-on to the Global Enteric Multicenter Study (GEMS).
Published Research